Combined effect of chronic kidney disease and peripheral arterial disease on all-cause mortality in a high-risk population

被引:84
作者
Liew, Yin Ping
Bartholomew, John R. [2 ]
Demirjian, Sevag
Michaels, Jeannie [3 ]
Schreiber, Martin J., Jr. [1 ]
机构
[1] Cleveland Clin, Dept Hypertens & Nephrol, Glickman Urol & Kidney Inst, Cleveland, OH 44195 USA
[2] Cleveland Clin, Sect Vasc Med, Dept Cardiovasc Med, Cleveland, OH 44195 USA
[3] Cleveland Clin, Qual Management Dept, Cleveland, OH 44195 USA
来源
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 3卷 / 04期
关键词
D O I
10.2215/CJN.04411007
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background and objectives: Chronic kidney disease (estimated glomerular filtration rate < 60 ml/min per 1.73 m(2)) and peripheral arterial disease (ankle-brachial index < 0.9) independently predict mortality. It was hypothesized that the risk for death is higher in patients with both chronic kidney disease and peripheral arterial disease compared with those with chronic kidney disease or peripheral arterial disease alone. Design, setting, participants, & measurements: A total of 1079 patients who had an ankle-brachial index and serum creatinine recorded within 90 d of each other in 1999 were studied retrospectively. Glomerular filtration rate was estimated using the Modification of Diet in Renal Disease equation. Patients were categorized into four groups: Chronic kidney disease and peripheral arterial disease, chronic kidney disease alone, peripheral arterial disease alone, or no chronic kidney disease or peripheral arterial disease. Results: The overall 6-yr mortality rate was 28% (n = 284). Patients with both chronic kidney disease and peripheral arterial disease had the highest mortality rate (45%) compared with patients with chronic kidney disease alone (28%), peripheral arterial disease alone (26%), and neither condition (18%). After adjustment for clinical and demographic variables, the chronic kidney disease and peripheral arterial disease group had an increased odds for death when compared with the no chronic kidney disease or peripheral arterial disease group or the single disease groups. Conclusions: These findings indicate that patients with both chronic kidney disease and peripheral arterial disease have a significantly higher risk for death than patients with either disease alone.
引用
收藏
页码:1084 / 1089
页数:6
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