Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice

被引：8

作者：

Ismail, Tabasum ^{[2
]}

Shafi, Syed ^{[3
]}

Gupta, Amit ^{[1
,2
]}

Khajuria, Anamika ^{[2
]}

Sidiq, Tabasum ^{[2
]}

Reddy, Doma Mahendhar ^{[2
]}

Alam, M. Sarwar ^{[3
]}

Qazi, G. N. ^{[3
]}

Kumar, H. M. Sampath ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Integrat Med, Synthet & Biol Chem Div, Jammu 180001, India

[3] Hamdard Univ, Fac Sci, Dept Chem, New Delhi 110062, India

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 11期

关键词：

Adjuvants; Lipopeptides; Lysine; Th1; PEPTIDES;

D O I：

10.1016/j.intimp.2011.07.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial lipoproteins and their synthetic analogs are strong immune modulators of the early host responses. In view of the strong adjuvanticity of bacterial lipopeptide mimics bearing lysine residues, a focused library of lipidated dipeptides and tripeptides has been synthesized with a view to understand the pattern of activity vis a vis the site and extent of lipidation. Compounds 4, 5 and 14 stimulate OVA specific IgG titer, neutralization of antibodies (IgG1 and IgG2a). T lymphocyte sub-sets (CD4/CD8) and its production of soluble mediators for Th1 (IFN-gamma)/Th2 (IL-4) cytokines and costimulatory molecules (CD80/CD86) which are ideal traits of immune adjuvants. The results support lipidated lysine dipeptides as potent enhancers of humoral and cell mediated immune responses and thus might become promising immune-adjuvants for self adjuvanted vaccines. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1855 / 1863

页数：9

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