The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial

被引：40

作者：

Akuffo, Kwadwo Owusu ^{[1
]}

Beatty, Stephen ^{[1
]}

Peto, Tunde ^{[2
]}

Stack, Jim ^{[1
]}

Stringham, Jim ^{[3
]}

Kelly, David ^{[1
]}

Leung, Irene ^{[4
,5
]}

Corcoran, Laura ^{[1
]}

Nolan, John M. ^{[1
]}

机构：

[1] Waterford Inst Technol, Nutr Res Ctr Ireland, Sch Hlth Sci, Macular Pigment Res Grp, Waterford, Ireland

[2] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

[3] Univ Georgia, Dept Physiol & Pharmacol, Nutr Neurosci Lab, Athens, GA 30602 USA

[4] Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England

[5] UCL Inst Ophthalmol, London, England

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2017年 / 58卷 / 12期

基金：

欧洲研究理事会;

关键词：

randomized clinical trial; lutein; zeaxanthin; meso-zeaxanthin; macular pigment; age-related macular degeneration; visual function; visual acuity; contrast sensitivity; NEI VFQ-25; photostress recovery time; reading performance; glare disability; retinal straylight; BASE-LINE-CHARACTERISTICS; CONTRAST SENSITIVITY; EYE DISEASE; SURGICAL REMOVAL; ZEAXANTHIN; PIGMENT; LUTEIN; CAROTENOIDS; CATARACT; PREVALENCE;

D O I：

10.1167/iovs.16-21192

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. METHODS. In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61). Visual function was assessed using best-corrected visual acuity, contrast sensitivity (CS), glare disability, retinal straylight, photostress recovery time, reading performance, and the National Eye Institute Visual Function Questionnaire-25. Macular pigment was measured using customized heterochromatic flicker photometry. RESULTS. There was a statistically significant improvement in the primary outcome measure (letter CS at 6 cycles per degree [6 cpd]) over time (P = 0.013), and this observed improvement was statistically comparable between interventions (P = 0.881). Statistically significant improvements in several secondary outcome visual function measures (letter CS at 1.2 and 2.4 cpd; mesopic and photopic CS at all spatial frequencies; mesopic glare disability at 1.5, 3, and 6 cpd; photopic glare disability at 1.5, 3, 6, and 12 cpd; photostress recovery time; retinal straylight; mean and maximum reading speed) were also observed over time (P < 0.05, for all), and were statistically comparable between interventions (P > 0.05, for all). Statistically significant increases in macular pigment at all eccentricities were observed over time (P < 0.0005, for all), and the degree of augmentation was statistically comparable between interventions (P > 0.05). CONCLUSIONS. Antioxidant supplementation in patients with nonadvanced age-related macular degeneration results in significant increases in macular pigment and improvements in CS and other measures of visual function.

引用

页码：5347 / 5360

页数：14

共 47 条

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