Allyl sulfones as precursors to allylzincs in the palladium-catalyzed zinc-ene cyclization: Highly efficient synthesis of enantiopure (-)-erythrodiene

被引：37
|
作者：
Deng, K [1 ]
Chalker, J [1 ]
Yang, A [1 ]
Cohen, T [1 ]
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 17期
关键词：
D O I：
10.1021/ol051049i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Easily prepared allyl phenyl sulfones, capable of introduction of the alkene by electrophilic alpha-substitution, are superior to allyl acetates as substrates for Pd-catalyzed Zn-ene cyclizations, providing C5 or C4N rings with cis-1,2-vinyl and -CH2Zn substituents. Several examples, with different methods of substrate preparation, are presented.
引用
收藏
页码：3637 / 3640
页数：4
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