CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA

被引：32
|
作者：
Coutinho-Camillo, Claudia Malheiros [1 ]
Lourenco, Silvia Vanessa [2 ]
Nishimoto, Ines Nobuko [3 ]
Kowalski, Luiz Paulo [3 ]
Soares, Fernando Augusto [1 ,2 ]
机构：
[1] Hosp AC Camargo Fund Antonio Prudente, Dept Anat Pathol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, Sao Paulo, Brazil
[3] Hosp AC Camargo Fund Antonio Prudente, Dept Otorhinolaryrigol & Head & Neck Surg, Sao Paulo, Brazil
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
caspases; oral squamous cell carcinoma; tissue microarray; immunohistochemistry; apoptosis; LUNG-CANCER; APOPTOSIS; POLYMORPHISMS; TONGUE; GENES; BCL-2; RISK; P53;
D O I：
10.1002/hed.21602
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. Methods. By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. Results. All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC. Conclusion. This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1191-1198, 2011
引用
收藏
页码：1191 / 1198
页数：8
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