CD146: the unveiling of a pro-angiogenic netrin receptor

被引：11
|
作者：
St Croix, Brad [1 ]
机构：
[1] NCI, Tumor Angiogenesis Sect, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA
来源：
CELL RESEARCH | 2015年 / 25卷 / 05期
关键词：
D O I：
10.1038/cr.2015.42
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Netrin-1, a classic neuronal guidance cue, can promote angiogenesis under certain developmental and pathological conditions, but key receptors on vascular endothelium have remained elusive. A recent study published in Cell Research by Tu et al. reveals that CD146, an endothelial receptor of the immunoglobulin superfamily, binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.
引用
收藏
页码：533 / 534
页数：2
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