Leptomeningeal disease in oligodendroglial tumors: a population-based study

被引：7

作者：

Roldan, Gloria ^{[1
,2
]}

Chan, Jennifer ^{[1
,3
]}

Eliasziw, Misha ^{[4
]}

Cairncross, J. Gregory ^{[1
,5
]}

Forsyth, Peter A. ^{[1
,2
,5
]}

机构：

[1] Tom Baker Canc Clin, Clark H Smith Brain Tumor Ctr, Alberta Hlth Serv, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Oncol, Calgary, AB T2N 4N2, Canada

[3] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 4N2, Canada

[4] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 4N2, Canada

[5] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada

来源：

JOURNAL OF NEURO-ONCOLOGY | 2011年 / 104卷 / 03期

关键词：

Oligodendroglial tumors; Leptomeningeal spread; PHASE-III TRIAL; ANAPLASTIC OLIGODENDROGLIOMA; SURVIVAL; CHEMOTHERAPY; RADIOTHERAPY; PROGNOSIS; 1P;

D O I：

10.1007/s11060-011-0551-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this population-based study, we determined the frequency and clinical characteristics of leptomeningeal disease (LMD) developing in the context of oligodendroglial tumors (oligodendrogliomas and oligoastrocytomas). LMD occurred in only 3.9% (8/204) of oligodendroglial tumors and in patients with more recurrences [mean 2.88 vs. 1.27 in LMD and non-LMD, respectively (p = 0.001)]. In contrast to LMD from systemic solid tumors, the median survival following the diagnosis of LMD in oligodendroglial tumors was surprisingly long at 22 months (95% CI 11-33 months). Treatment with oral chemotherapy seemed as effective as more aggressive treatments (e.g. repeat RT or intrathecal chemotherapy) in these patients.

引用

页码：811 / 815

页数：5

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