Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV

被引：5

作者：

McClymont, Elisabeth ^{[1
]}

Ogilvie, Gina ^{[2
,3
]}

Albert, Arianne ^{[3
]}

Johnston, Angela ^{[4
]}

Raboud, Janet ^{[5
,6
]}

Walmsley, Sharon ^{[5
,6
]}

Lipsky, Nancy ^{[3
]}

Loutfy, Mona ^{[7
]}

Trottier, Sylvie ^{[8
]}

Smaill, Fiona ^{[9
]}

Yudin, Mark H. ^{[7
,10
]}

Klein, Marina B. ^{[11
]}

Harris, Marianne ^{[12
]}

Wobeser, Wendy ^{[13
,14
]}

Bitnun, Ari ^{[15
]}

Kakkar, Fatima ^{[16
,17
]}

Samson, Lindy ^{[18
]}

Brophy, Jason ^{[19
]}

Karatzios, Christos ^{[20
,21
]}

Money, Deborah ^{[1
]}

机构：

[1] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada

[2] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada

[3] Womens Hlth Res Inst, Vancouver, BC, Canada

[4] Univ British Columbia, Fac Med, Vancouver, BC, Canada

[5] Univ Hlth Network, Univ Toronto, Toronto Gen Hosp Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[7] Univ Toronto, Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON, Canada

[8] Univ Laval, Infect Dis Res Ctr, Quebec City, PQ, Canada

[9] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

[10] Univ Toronto, St Michaels Hosp, Dept Obstet & Gynecol, Toronto, ON, Canada

[11] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[12] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[13] Queens Univ, Dept Publ Hlth, Kingston, ON, Canada

[14] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada

[15] Univ Toronto, Hosp Sick Children, Dept Paediat, Toronto, ON, Canada

[16] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ, Canada

[17] CHU St Justine, Ctr Maternel & Infantile SIDA, Montreal, PQ, Canada

[18] Univ Ottawa, Dept Paediat, Ottawa, ON, Canada

[19] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON, Canada

[20] Univ Montreal, Ctr Hosp Univ St Justine, Dept Paediat, Montreal, PQ, Canada

[21] McGill Univ, Montreal Childrens Hosp, Dept Pediat, Hlth Ctr, Montreal, PQ, Canada

来源：

VACCINE | 2020年 / 38卷 / 15期

关键词：

HPV vaccine; HIV; HPV; Women; HUMAN-PAPILLOMAVIRUS VACCINE; ANTIBODY-RESPONSES; IMMUNOGENICITY; HUMAN-PAPILLOMAVIRUS-16; INFECTION; EFFICACY;

D O I：

10.1016/j.vaccine.2020.02.075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HPV vaccination schedules have changed as evidence has supported reduced dosing and extended intervals. Women living with HIV (WLWH) represent an important population with no data on alternative dosing. Girls and WLWH received quadrivalent HPV (qHPV) vaccine in a pan-Canadian study of immunogenicity and efficacy. Serology was performed at months 0/2/7/12/18/24. Medical and sexual history was collected throughout. Linear regression was used to determine if spacing of doses was associated with peak antibody titer. Multivariable analyses demonstrated significant relationships between peak antibody titer and time to blood draw post last vaccine dose, naivety to the relevant HPV type, and HIV viral load for all qHPV types. There was a significant relationship between peak HPV16/18 antibody titer and age. Taking age, time to serology, CD4 cell count, CD4 nadir, HIV viral load, and HPV naivety into account, spacing of the three qHPV vaccine doses did not significantly impact peak antibody titers. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：3073 / 3078

页数：6

共 22 条

[1]

[Anonymous], CLIN INFECT DIS

[2] Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors [J].

Arbyn, Marc ;

Xu, Lan ;

Simoens, Cindy ;

Martin-Hirsch, Pierre P. L. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2018, (05)

[3] End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24-45 years of age [J].

Castellsague, X. ;

Munoz, N. ;

Pitisuttithum, P. ;

Ferris, D. ;

Monsonego, J. ;

Ault, K. ;

Luna, J. ;

Myers, E. ;

Mallary, S. ;

Bautista, O. M. ;

Bryan, J. ;

Vuocolo, S. ;

Haupt, R. M. ;

Saah, A. .

BRITISH JOURNAL OF CANCER, 2011, 105 (01) :28-37

[4] Incidence and progression of cervical lesions in women with HIV: a systematic global review [J].

Denslow, Sheri A. ;

Rositch, Anne F. ;

Firnhaber, Cynthia ;

Ting, Jie ;

Smith, Jennifer S. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2014, 25 (03) :163-177

[5] Optimization and validation of a multiplexed Luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18 [J].

Dias, D ;

Van Doren, J ;

Schlottmann, S ;

Kelly, S ;

Puchalski, D ;

Ruiz, W ;

Boerckel, P ;

Kessler, J ;

Antonello, JM ;

Green, T ;

Brown, M ;

Smith, J ;

Chirmule, N ;

Barr, E ;

Jansen, KU ;

Esser, MT .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (08) :959-969

[6] Immunogenicity of 2 Doses of HPV Vaccine in Younger Adolescents vs 3 Doses in Young Women A Randomized Clinical Trial [J].

Dobson, Simon R. M. ;

McNeil, Shelly ;

Dionne, Marc ;

Dawar, Meena ;

Ogilvie, Gina ;

Krajden, Mel ;

Sauvageau, Chantal ;

Scheifele, David W. ;

Kollmann, Tobias R. ;

Halperin, Scott A. ;

Langley, Joanne M. ;

Bettinger, Julie A. ;

Singer, Joel ;

Money, Deborah ;

Miller, Dianne ;

Naus, Monika ;

Marra, Fawziah ;

Young, Eric .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (17) :1793-1802

[7]

Fiore Anthony E., 2007, Morbidity and Mortality Weekly Report, V56, P1

[8] The effect of a booster dose of quadrivalent or bivalent HPV vaccine when administered to girls previously vaccinated with two doses of quadrivalent HPV vaccine [J].

Gilca, Vladimir ;

Sauvageau, Chantal ;

Boulianne, Nicole ;

De Serres, Gatson ;

Crajden, Mel ;

Ouakki, Manale ;

Trevisan, Andrea ;

Dionne, Marc .

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (03) :732-738

[9] HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine [J].

Joura, Elmar A. ;

Kjaer, Susanne K. ;

Wheeler, Cosette M. ;

Sigurdsson, Kristjan ;

Iversene, Ole-Erik ;

Hernandez-Avila, Mauricio ;

Perez, Gonzalo ;

Brown, Darron R. ;

Koutsky, Laura A. ;

Tay, Eng Hseon ;

Garcia, Patricia ;

Ault, Kevin A. ;

Garland, Suzanne M. ;

Leodolter, Sepp ;

Olssonn, Sven-Eric ;

Tang, Grace W. K. ;

Ferris, Daron G. ;

Paavonen, Jorma ;

Lehtinen, Matti ;

Steben, Marc ;

Bosch, Xavier ;

Dillner, Joakim ;

Kurmanv, Robert J. ;

Majewski, Slawomir ;

Munoz, Nubia ;

Myers, Evan R. ;

Villa, Luisa L. ;

Taddeo, Frank J. ;

Roberts, Christine ;

Tadesse, Amha ;

Bryan, Janine ;

Lupinaccia, Lisa C. ;

Giacoletti, Katherine E. D. ;

Lu, Shuang ;

Vuocolo, Scott ;

Hesley, Teresa M. ;

Haupt, Richard M. ;

Barr, Eliav .

VACCINE, 2008, 26 (52) :6844-6851

[10] Immunogenicity of Quadrivalent HPV Vaccine Among Girls 11 to 13 Years of Age Vaccinated Using Alternative Dosing Schedules: Results 29 to 32 Months After Third Dose [J].

LaMontagne, D. Scott ;

Vu Dinh Thiem ;

Vu Minh Huong ;

Tang, Yuxiao ;

Neuzil, Kathleen M. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (08) :1325-1334

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