Role of memory T cells and perspectives for intervention in organ transplantation

被引：12
作者：
Lin, Kailin [1 ]
Chen, Song [1 ,2 ,3 ]
Chen, Gang [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Organ Transplantat, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
[2] Minist Educ, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
[3] Minist Publ Hlth, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
memory T cells; transplantation; allograft rejection; tolerance; therapy; ANTITHYMOCYTE GLOBULIN; ALLOGRAFT-REJECTION; HOMEOSTATIC PROLIFERATION; LIVER-TRANSPLANTATION; CD40-INDEPENDENT HELP; MEDIATED REJECTION; CARDIAC ALLOGRAFT; UP-REGULATION; B-CELLS; BLOCKADE;
D O I：
10.3389/fimmu.2015.00473
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.
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页数：6
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