Amplified fluorescent molecular probes based on 1,3,5,7-tetrasubstituted adamantane

被引：13

作者：

Martin, VV ^{[1
]}

Alferiev, IS ^{[1
]}

Weis, AL ^{[1
]}

机构：

[1] Lipitek Int Inc, San Antonio, TX 78245 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 02期

关键词：

adamantanes; fluorescence; molecular design;

D O I：

10.1016/S0040-4039(98)02280-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of fluorescent labels containing multiple fluorescein moieties attached to a bridgehead-substituted adamantane has been synthesized. Molecules containing two, three or four fluorescein residues were prepared and their fluorescence was measured. The rigid adamantane core prevents fluorescein moieties from intramolecular collisions, thus precluding mutual fluorescence quenching. proposed design allows building the molecular probes with amplified fluorescence signal by combining several fluorophores in a molecule. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：223 / 226

页数：4

共 8 条

[1] Synthesis of a novel pyrene-containing nucleoside and its incorporation into oligonucleotides [J].