mTOR complex 2 signaling and functions

被引：465

作者：

Oh, Won Jun ^{[1
]}

Jacinto, Estela ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

来源：

CELL CYCLE | 2011年 / 10卷 / 14期

基金：

美国国家卫生研究院;

关键词：

mTOR; mTORC2; rictor; cancer; metabolism; ribosomes; protein synthesis; protein maturation; AGC kinases; growth factor signaling; PROTEIN-KINASE-C; MAMMALIAN TARGET; CELL-GROWTH; FKBP12-RAPAMYCIN-ASSOCIATED PROTEIN; MOTIF PHOSPHORYLATION; ENDOPLASMIC-RETICULUM; AKT PHOSPHORYLATION; ACTIN CYTOSKELETON; BINDING PARTNER; RAPAMYCIN TOR;

D O I：

10.4161/cc.10.14.16586

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is known on the regulation and functions of mTORC1 due to availability of a natural compound, rapamycin, that inhibits this complex. Studies that define mTORC2 cellular functions and signaling have lagged behind. The development of pharmacological inhibitors that block mTOR kinase activity, and thereby inhibit both mTOR complexes, along with availability of mice with genetic knockouts in mTOR complex components have now provided new insights on mTORC2 function and regulation. Since prolonged effects of rapamycin can also disrupt mTORC2, it is worth to re-evaluate the contribution of this less-studied mTOR complex in cancer, metabolic disorders and aging. In this review, we focus on recent developments on mammalian mTORC2 signaling mechanisms and its cellular and tissue-specific functions.

引用

页码：2305 / 2316

页数：12

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