Imaging Patterns of Brain Development and their Relationship to Cognition

被引：149

作者：

Erus, Guray ^{[1
,2
]}

Battapady, Harsha ^{[1
,2
]}

Satterthwaite, Theodore D. ^{[1
,2
,3
]}

Hakonarson, Hakon ^{[4
]}

Gur, Raquel E. ^{[3
]}

Davatzikos, Christos ^{[1
,2
]}

Gur, Ruben C. ^{[3
]}

机构：

[1] Univ Penn, Dept Radiol, Sect Biomed Image Anal, Philadelphia, PA 19104 USA

[2] Univ Penn, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

来源：

CEREBRAL CORTEX | 2015年 / 25卷 / 06期

关键词：

age prediction; brain development index; DTI; MRI; SVR; WHITE-MATTER DEVELOPMENT; CORTICAL DEVELOPMENT; PROCESSING SPEED; SEX-DIFFERENCES; CHILDHOOD; ADOLESCENCE; MATURATION; CHILDREN; MRI; AGE;

D O I：

10.1093/cercor/bht425

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We present a brain development index (BDI) that concisely summarizes complex imaging patterns of structural brain maturation along a single dimension using a machine learning methodology. The brain was found to follow a remarkably consistent developmental trajectory in a sample of 621 subjects of ages 8-22 participating in the Philadelphia Neurodevelopmental Cohort, reflected by a cross-validated correlation coefficient between chronologic age and the BDI of r = 0.89. Critically, deviations from this trajectory related to cognitive performance. Specifically, subjects whose BDI was higher than their chronological age displayed significantly superior cognitive processing speed compared with subjects whose BDI was lower than their actual age. These results indicate that the multiparametric imaging patterns summarized by the BDI can accurately delineate trajectories of brain development and identify individuals with cognitive precocity or delay.

引用

页码：1676 / 1684

页数：9

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