Cytokine production in hearts of Trypanosoma cruzi-infected CBA mice: Do cytokine patterns in chronic stage reflect the establishment of myocardial pathology?

被引：25
|
作者：
Sunnemark, D
Ulfgren, AK
Orn, A
Harris, RA
机构：
[1] KAROLINSKA INST,CTR MICROBIOL & TUMOR BIOL,S-17177 STOCKHOLM,SWEDEN
[2] KAROLINSKA HOSP,DEPT RHEUMATOL,S-10401 STOCKHOLM,SWEDEN
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1996年 / 44卷 / 05期
关键词：
D O I：
10.1046/j.1365-3083.1996.d01-328.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The authors analysed cytokine production in hearts of Trypanosoma cruzi-infected CBA-J mice by in situ immunocytochemical staining, Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated production of IL-4, IL-6 and TNF-alpha. Cytokine production was characterized by IL-4, IL-5, IL-6 and TNF-alpha in the chronic heart, and numbers of CD4 and CD8 cells were more equal. At this stage, calcified infarctions and associated fibrosis were apparent, mimicking chronic human Chagas' heart pathology. The authors consider the CBA mouse an appropriate model of chronic T. infection, and suggest that local cytokine production reflects establishment of heart pathology.
引用
收藏
页码：421 / 429
页数：9
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