Cytokine production in hearts of Trypanosoma cruzi-infected CBA mice: Do cytokine patterns in chronic stage reflect the establishment of myocardial pathology?

被引：26
作者：
Sunnemark, D
Ulfgren, AK
Orn, A
Harris, RA
机构：
[1] KAROLINSKA INST,CTR MICROBIOL & TUMOR BIOL,S-17177 STOCKHOLM,SWEDEN
[2] KAROLINSKA HOSP,DEPT RHEUMATOL,S-10401 STOCKHOLM,SWEDEN
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1996年 / 44卷 / 05期
关键词：
D O I：
10.1046/j.1365-3083.1996.d01-328.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The authors analysed cytokine production in hearts of Trypanosoma cruzi-infected CBA-J mice by in situ immunocytochemical staining, Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated production of IL-4, IL-6 and TNF-alpha. Cytokine production was characterized by IL-4, IL-5, IL-6 and TNF-alpha in the chronic heart, and numbers of CD4 and CD8 cells were more equal. At this stage, calcified infarctions and associated fibrosis were apparent, mimicking chronic human Chagas' heart pathology. The authors consider the CBA mouse an appropriate model of chronic T. infection, and suggest that local cytokine production reflects establishment of heart pathology.
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收藏
页码：421 / 429
页数：9
相关论文
共 52 条
[1]   AN AGE-RELATED GAMMA-DELTA T-CELL SUPPRESSOR ACTIVITY CORRELATES WITH THE OUTCOME OF AUTOIMMUNITY IN EXPERIMENTAL TRYPANOSOMA-CRUZI INFECTION [J].
CARDILLO, F ;
FALCAO, RP ;
ROSSI, MA ;
MENGEL, J .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (10) :2597-2605
[2]   Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: Role of NK cells [J].
Cardillo, F ;
Voltarelli, JC ;
Reed, SG ;
Silva, JS .
INFECTION AND IMMUNITY, 1996, 64 (01) :128-134
[3]   T cell receptor V beta repertoire in the thymus and spleen of mice infected with Trypanosoma cruzi [J].
Cardoni, RL ;
Antunez, MI ;
Orn, A ;
Gronvik, KO .
CELLULAR IMMUNOLOGY, 1996, 169 (02) :238-245
[4]  
DEMORAES MDCL, 1994, SCAND J IMMUNOL, V39, P51
[5]   IMMUNOHISTOCHEMICAL CHARACTERIZATION OF INFILTRATING CELLS IN HUMAN CHRONIC CHAGASIC MYOCARDITIS - COMPARISON WITH MYOCARDIAL REJECTION PROCESS [J].
HIGUCHI, MD ;
GUTIERREZ, PS ;
AIELLO, VD ;
PALOMINO, S ;
BOCCHI, E ;
KALIL, J ;
BELLOTTI, G ;
PILEGGI, F .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1993, 423 (03) :157-160
[6]  
HOFT DF, 1993, J IMMUNOL, V151, P7038
[7]  
HONTEBEYRIEJOSK.M, 1992, MEM I OSWALDO CRUZ S, V5, P101
[8]   MURINE TRYPANOSOMA-CRUZI INFECTION - A ROLE FOR TH2 CELLS IN THE IMMUNOPATHOLOGY OF CHRONIC INFECTION [J].
HONTEBEYRIEJOSKOWICZ, M .
RESEARCH IN IMMUNOLOGY, 1991, 142 (02) :141-143
[9]   THE BIOLOGY OF INTERLEUKIN-6 [J].
KISHIMOTO, T .
BLOOD, 1989, 74 (01) :1-10
[10]   Increased expression and secretion of ICAM-1 during experimental infection with Trypanosoma cruzi [J].
Laucella, S ;
Salcedo, R ;
CastanosVelez, E ;
Riarte, A ;
DeTitto, EH ;
Patarroyo, M ;
Orn, A ;
Rottenberg, ME .
PARASITE IMMUNOLOGY, 1996, 18 (05) :227-239
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