Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation

被引：22

作者：

Bednar, Maria M. ^{[1
]}

Hauser, Blake M. ^{[1
]}

Zhou, Shuntai ^{[1
]}

Jacobson, Jeffrey M. ^{[4
,5
,6
]}

Eron, Joseph J., Jr. ^{[2
]}

Frank, Ian ^{[7
]}

Swanstrom, Ronald ^{[3
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Campus Box 7295, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Div Infect Dis, Campus Box 7295, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Biochem & Biophys, Campus Box 7295, Chapel Hill, NC 27599 USA

[4] Temple Univ, Dept Med, Philadelphia, PA 19122 USA

[5] Temple Univ, Dept Neurosci, Philadelphia, PA 19122 USA

[6] Temple Univ, Ctr Translat AIDS Res, Lewis Katz Sch Med, Philadelphia, PA 19122 USA

[7] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷 / 03期

关键词：

HIV-1; rebound virus; tropism; genetic diversity; reservoir; IDENTIFICATION; REPLICATION; RESERVOIR; CELLS;

D O I：

10.1093/infdis/jiw172

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus-infected people discontinuing therapy experience a rebound in the virus level (hereafter, "rebound virus") from a persistent reservoir. We examined 10 samples from patients in AIDS Clinical Trials Group study A5068 with rebound virus, using single-genome amplification and Primer ID deep sequencing, to assess env genetic diversity of the virus population. Most rebound-virus populations showed significant diversity. All env examined required high levels of CD4 for entry, consistent with selection of replication in CD4(+) T cells. These results indicate that most people discontinuing therapy release a diverse population of virus and that this released virus has entry features of virus selected for replication in CD4(+) T cells, rather than in myeloid cells.

引用

页码：403 / 407

页数：5

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