Potential Causes of False-Negative Interpretations in 68Ga-PSMA PET/CT for the Detection of Local and Recurrent Prostate Cancer An Underexposed Issue

被引：8
作者：
Yakar, Derya
Noordzij, Walter
Kwee, Thomas C.
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Med Imaging Ctr, Dept Radiol, Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Med Imaging Ctr, Dept Nucl Med, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Med Imaging Ctr, Dept Mol Imaging, Groningen, Netherlands
来源：
CLINICAL NUCLEAR MEDICINE | 2020年 / 45卷 / 01期
关键词：
Ga-68-PSMA PET/CT; false-negative; multiparametric MRI; prostate cancer;
D O I：
10.1097/RLU.0000000000002750
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Ga-68-PSMA PET/CT has emerged as a highly promising diagnostic method for the evaluation of prostate cancer. Although it is increasingly recognized that its specificity is imperfect, data on false-negatives in the prostate have been underreported. We present 3 cases with false-negatives for local (recurrent) prostate cancer on Ga-68-PSMA PET/CT, using multiparametric MRI and histopathology as reference standard. Metal artifact of prostate gold markers placed for external beam radiation therapy, lowlevel of PSMAuptake, and bladder spillover are potential causes of misinterpretation. Awareness of these diagnostic pitfalls may improve Ga-68-PSMA PET/CT interpretation.
引用
收藏
页码：E32 / E35
页数：4
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