Gadolinium-doped Cu-In-Zn-S quantum dots: one-pot aqueous synthesis and multimodal bioimaging

被引：0
作者：
Zhang, L. [1 ]
Wan, Y. [1 ]
Xue, J. [1 ]
Duan, W. [1 ]
Chen, D. [1 ]
Wu, Y. [1 ]
Wang, J. [1 ]
Xu, D. [1 ]
Liu, D. [2 ]
机构：
[1] Qiqihar Med Univ, Coll Med Technol, Qiqihar 161006, Heilongjiang, Peoples R China
[2] Qiqihar Univ, Commun & Elect Engn Inst, Qiqihar 161006, Heilongjiang, Peoples R China
来源：
JOURNAL OF OVONIC RESEARCH | 2021年 / 17卷 / 05期
关键词：
GCIZS QDs; gadolinium doped; multimodality imaging; GSH capped; HIGHLY LUMINESCENT; FACILE SYNTHESIS; NANOCRYSTALS; QDS;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
We report a one-pot method to directly synthesize magnetic resonance/fluorescence multimodal imaging gadolinium-doped Cu-In-Zn-S quantum dots(GCIZS QDs) in aqueous media by using bio-compatible glutathione (GSH) as capping ligand and stabilizer. The optical features and structure of the GCIZS QDs have been characterized by UV-vis and fluorescence spectroscopy, XRD, TEM, and FT-IR. As a result, The GCIZS QDs possessed a strong fluorescence and r(1) value of 4.015 mM(-1)s(-1) at the Cu/Gd ratio of 1/2. Furthermore, the GCIZS QDs were good water solubility and less cytotoxic up to 250 mu g/mL in HUVEC cells. The red emission GCIZS QDs from the MDA-MB-231cells was clearly observed under microscope. It indicated that the GCIZS QDs present great potential as magnetic resonance / fluorescence multimodal imaging contrast agents for biological labels.
引用
收藏
页码：471 / 478
页数：8
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