Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network

被引：597

作者：

Rosen, H

Goetzl, EJ ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[3] Univ Calif San Francisco, Dept Microbiol Immunol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1650

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of G-protein-coupled receptors to control cellular differentiation and survival, as well as the vital functions of several types of immune cell. In this Review article, we discuss recent results that indicate that S1P and its receptors are required for the emigration of thymocytes from the thymus, the trafficking of lymphocytes in secondary lymphoid organs and the migration of B cells into splenic follicles. In an autocrine manner, through interactions with different G-protein-coupled receptors, S1P also enhances optimal mast-cell migration and release of pro-inflammatory mediators in allergic reactions. S1P - S1P- receptor regulatory systems might therefore be novel targets for the therapy of diverse immunological diseases.

引用

收藏

页码：560 / 570

页数：11

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