On the feasibility of recognition of nucleic acid sequences by metal-ion-carrying oligonucleotides

被引：45

作者：

Taherpour, Sharmin ^{[1
]}

Golubev, Oleg ^{[1
]}

Lonnberg, Tuomas ^{[1
]}

机构：

[1] Univ Turku, Dept Chem, Vatselankatu 2, FIN-20014 Turku, Finland

来源：

INORGANICA CHIMICA ACTA | 2016年 / 452卷

基金：

芬兰科学院;

关键词：

Metal complexes; Base pairing; Oligonucleotide; Hybridization; Sequence recognition; MEDIATED BASE-PAIRS; PROTON-MAGNETIC-RESONANCE; MIXED-LIGAND COMPLEXES; C-AG-C; HG-II; CRYSTAL-STRUCTURE; BUILDING-BLOCK; DNA DUPLEXES; SOFT ACIDS; BINDING;

D O I：

10.1016/j.ica.2016.01.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal-ion-mediated base pairing has been extensively studied in the context of DNA nanotechnology or expansion of the genetic alphabet but only recently with the aim of recognition of natural nucleic acid sequences. This review article focuses on the attempts to utilize metal-ion-carrying oligonucleotides as high-affinity probes for nucleic acids but relevant studies carried out at the monomer level are also discussed. Special emphasis is given to challenges inherent to this approach, such as the limited recognition elements of the canonical nucleobases and the scarcity of suitable metal ions in the intracellular medium. Finally, potential ways to overcome these challenges are proposed. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：43 / 49

页数：7

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