Comparison of in vivo dopamine D2 receptor binding of [123I]AIBZM and [123I]IBZM in rat brain

[I-123]AIBZM, (S)-5-[I-123]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen(TM) method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [I-123]AIBZM was significantly lower, however the striatum/cerebellum ratio (2h p.i.) was higher than that of [I-123]IBZM. Because of the high affinity and its possibly lower unspecific binding compared to [I-123]IBZM, [I-123]AIBZM may be a potential imaging agent for the D2 dopamine receptor, (C) 2001 Elsevier Science Inc. All rights reserved.