Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene

被引：45
作者：
Yamada, R
Suzuki, A
Chang, XT
Yamamoto, K
机构：
[1] Inst Phys & Chem Res, SNP Res Ctr, Lab Rheumat Dis, Tsurumi Ku, Kanagawa 2300045, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan
来源：
TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 11期
关键词：
D O I：
10.1016/j.molmed.2003.09.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies using linkage disequilibrium and SNPs uncovered a rheumatoid arthritis (RA)-susceptible haplotype in the gene encoding peptidylarginine deiminase (PADI) type 4. This gene is one of four known PADI genes that encode enzymes to change arginine into citrulline in proteins. Post-translational modifications of proteins, including peptidyl citrullination, are related to autoimmunity, and peptidyl citrulline is a known target of one of the most RA-specific autoantibodies. Further research on PAD14, its citrullination of native peptides, subsequent breakdown of tolerance, and the role of these peptides in the development of RA, is expected to bring a better understanding of autoimmunity and arthritis, and advancements in the medical care of RA.
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收藏
页码：503 / 508
页数：6
相关论文
共 69 条
[1]  
Abu Rus'd A, 1999, EUR J BIOCHEM, V259, P660
[2]  
AHO K, 1986, J RHEUMATOL, V13, P899
[3]   Apoptosis in systemic lupus erythematosus - Clinical implications [J].
Andrade, F ;
Casciola-Rosen, L ;
Rosen, A .
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2000, 26 (02) :215-+
[4]   The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase [J].
Arentz-Hansen, H ;
Körner, R ;
Molberg, O ;
Quarsten, H ;
Vader, W ;
Kooy, YMC ;
Lundin, KEA ;
Koning, F ;
Roepstorff, P ;
Sollid, LM ;
McAdam, SN .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :603-612
[5]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[6]   Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages [J].
Asaga, H ;
Yamada, M ;
Senshu, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 243 (03) :641-646
[7]  
Asaga H, 2001, J LEUKOCYTE BIOL, V70, P46
[8]   Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors [J].
Bas, S ;
Perneger, TV ;
Seitz, M ;
Tiercy, JM ;
Roux-Lombard, P ;
Guerne, PA .
RHEUMATOLOGY, 2002, 41 (07) :809-814
[9]  
Bizzaro N, 2001, CLIN CHEM, V47, P1089
[10]   Genetic remodeling of protein glycosylation in vivo induces autoimmune disease [J].
Chui, D ;
Sellakumar, G ;
Green, RS ;
Sutton-Smith, M ;
McQuistan, T ;
Marek, KW ;
Morris, HR ;
Dell, A ;
Marth, JD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :1142-1147
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