The Therapeutic Potential of tRNA-derived Small RNAs in Neurodegenerative Disorders

被引：23

作者：

Tian, Haihua ^{[1
,2
,3
,4
]}

Hu, Zhenyu ^{[5
]}

Wang, Chuang ^{[1
,2
,3
]}

机构：

[1] Ningbo Univ, Ningbo Key Lab Behav Neurosci, Sch Med, Ningbo, Zhejiang, Peoples R China

[2] Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, Ningbo, Zhejiang, Peoples R China

[3] Ningbo Univ, Dept Physiol & Pharmacol, Sch Med, Ningbo, Zhejiang, Peoples R China

[4] Ningbo Kangning Hosp, Dept Lab Med, Ningbo, Zhejiang, Peoples R China

[5] Ningbo Kanning Hosp, Dept Child Psychiat, Ningbo, Zhejiang, Peoples R China

来源：

AGING AND DISEASE | 2022年 / 13卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DNA methylation; aging; adipocytes; adipose tissue; BROWN ADIPOSE-TISSUE; DNA METHYLATION PROFILE; FAT-CELL PROGENITORS; GENE-EXPRESSION; INSULIN-RESISTANCE; L-CARNITINE; IMPAIRED ADIPOGENESIS; ENERGY-METABOLISM; BEIGE ADIPOCYTES; PROGRAMMED LOSS;

D O I：

10.14336/AD.2021.0903

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging has been recognized to be a highly complex biological health problem with a high risk of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or emphysema, cancer and Alzheimer's disease. Particularly, age-related turnover in adipose tissue is a major contributor to metabolic syndromes and shortened lifespan. Adipocytes undergo senescence in early stage, which results in adipose tissue metabolic dysfunction, redistribution, and inflammation. The well-established association between DNA methylation (DNAm) and aging has been observed in the past few decades. Indeed, age-related alteration in DNAm is highly tissue-specific. This review intends to summarize the advancements how DNAm changes coupled with aging process in adipose tissue, by which DNAm regulates cellular senescence, metabolic function, adipokine secretion and beiging process in adipocytes. Elucidation of the effect of DNAm on adipose aging would have great potential to the development of epigenetic therapeutic strategies against aging-related diseases in clinical settings.

引用

页码：389 / 401

页数：13

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