Effect of temperature and ultraviolet irradiation on free radical scavenging activity of simvastatin

被引：0
|
作者：
Zdybel, Magdalena [1 ]
Pilawa, Barbara [1 ]
Chodurek, Ewa [2 ]
机构：
[1] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Biophys, Jednosci 8, PL-41200 Katowice, Poland
[2] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Biopharm, Katowice, Poland
来源：
SPECTROSCOPY LETTERS | 2022年 / 55卷 / 01期
关键词：
Electron paramagnetic resonance spectroscopy; free radicals; simvastatin; storage temperature; ultraviolet irradiation; ELECTRON-PARAMAGNETIC-RESONANCE; HUMAN-MELANOMA CELLS; EPR SPECTROSCOPY; AMINO-ACID; VALPROIC ACID; GAMMA; COMPLEXES; CENTERS; ALANINE; OXYGEN;
D O I：
10.1080/00387010.2021.2013895
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Simvastatin characterizes antioxidant, antitumor, anti-inflammatory, and anticoagulant properties. The aim of the study was to estimate free radical scavenging activity of simvastatin at different physical conditions by the use of electron paramagnetic resonance spectroscopy. Simvastatin was storage at room temperature, 37 degrees C, and 41 degrees C, and it was exposed to ultraviolet irradiation. The antioxidative character was stated for all the simvastatin samples, which quenched free radicals. The higher free radical scavenging activity revealed the heated simvastatin than that storage at room temperature. Simvastatin may be exposed to ultraviolet irradiation, but the storage temperature should not be increased. The kinetics indicates fast free radical interactions of the tested samples. Electron paramagnetic resonance spectroscopy is useful to optimization of storage conditions of simvastatin.
引用
收藏
页码：35 / 43
页数：9
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