Facile synthesis of CF3-substituted dienamides via one-pot tandem reactions

被引：6
作者：
Yuan, Zhe-Zhe [1 ]
Kong, Xiang-Wen [1 ]
Liu, Li-Hua [1 ]
Zhu, Hui-Xia [1 ]
Xiao, Hua [1 ,2 ]
机构：
[1] Hefei Univ Technol, Dept Pharmaceut Engn, Hefei 230009, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Dienamides; Aminolysis; Butenolide; Phosphine catalysis; One-pot; TRIFLUOROMETHYL KETONES; DIRECT AMIDATION; PHOSPHINE; CATALYST; CYCLOADDITION; DERIVATIVES; CYCLIZATIONS; CARBONATES; ESTERS; DBU;
D O I：
10.1016/j.cclet.2017.02.017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot reaction sequence of sequential phosphine-promoted tandem annulations of aryl trifluoromethyl ketones and MBH (Morita-Baylis-Hillman) carbonates and DBU-mediated aminolysis was developed. This method provides a step-economical approach to trifluoromethylated dienamides with diverse structural complexity from readily available starting materials in moderate yields. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1469 / 1472
页数：4
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