A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing

被引：161

作者：

Ishiguro, Kei-ichiro ^{[1
]}

Kim, Jihye ^{[1
,3
]}

Fujiyama-Nakamura, Sally ^{[2
]}

Kato, Shigeaki ^{[2
]}

Watanabe, Yoshinori ^{[1
,3
]}

机构：

[1] Univ Tokyo, Lab Chromosome Dynam, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

[2] Univ Tokyo, Lab Nucl Signaling, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1130032, Japan

来源：

EMBO REPORTS | 2011年 / 12卷 / 03期

关键词：

cohesin; meiosis; chromosome segregation; homologue synapsis; centromere; SISTER-CHROMATID COHESION; DOUBLE-STRAND BREAKS; POLO-LIKE KINASE; CHROMOSOME SEGREGATION; MEIOTIC RECOMBINATION; SYNAPTONEMAL COMPLEXES; PROMOTES SYNAPSIS; MAMMALIAN MEIOSIS; DNA RECOMBINATION; AXIAL ELEMENTS;

D O I：

10.1038/embor.2011.2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.

引用

页码：267 / 275

页数：9

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