Planning and analysis of cross-over trials in infertility

被引：19

作者：

Makubate, Boikanyo ^{[2
]}

Senn, Stephen ^{[1
]}

机构：

[1] Univ Glasgow, Dept Stat, Glasgow G12 9LL, Lanark, Scotland

[2] Univ Dundee, Coll Med Dent & Nursing, Dundee DD2 4BF, Scotland

来源：

STATISTICS IN MEDICINE | 2010年 / 29卷 / 30期

关键词：

cross-over trial; missing data; parallel group trial; infertility; Mantel-Haenszel; MALE SUBFERTILITY; INTRAUTERINE INSEMINATION; MARGINAL MODELS; DESIGN; PARALLEL; VIEW;

D O I：

10.1002/sim.3981

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examples of trials in infertility. An approach that may be used to compare designs via simulation is explained briefly. It is concluded that provided that cross-over trials in infertility are regarded as parallel group trials with extra information rather than as cross-over trials with missing information, their use may be more promising than that has previously been concluded. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：3203 / 3210

页数：8

共 20 条

[1]

[Anonymous], 2002, J WILEY

[2]

[Anonymous], CATEGORICAL DATA ANA

[3]

[Anonymous], 2003, DESIGN ANAL CROSS OV, DOI DOI 10.1201/9781420036091

[4] Controlled ovarian hyperstimulation and intrauterine insemination for treating male subfertility: a controlled study [J].

Cohlen, BJ ;

Velde, ERT ;

van Kooij, RJ ;

Looman, CWN ;

Habbema, JDF .

HUMAN REPRODUCTION, 1998, 13 (06) :1553-1558

[5] Crossover or parallel design in infertility trials? The discussion continues [J].

Cohlen, BJ ;

Velde, ERT ;

Looman, CWN ;

Eijckemans, R ;

Habbema, JDF .

FERTILITY AND STERILITY, 1998, 70 (01) :40-45

[6]

Daya S, 1999, FERTIL STERIL, V71, P771

[7] Pitfalls in the design and analysis of efficacy trials in subfertility [J].

Daya, S .

HUMAN REPRODUCTION, 2003, 18 (05) :1005-1009

[8] Bias in frequently reported analyses of subfertility trials [J].

Dias, Sofia ;

McNamee, Roseanne ;

Vail, Andy .

STATISTICS IN MEDICINE, 2008, 27 (27) :5605-5619

[9]

EZZET F, 1992, J R STAT SOC C-APPL, V41, P117

[10] Pregnancy rates in gonadotrophin stimulated cycles with timed intercourse or intrauterine insemination for the treatment of male subfertility [J].

Gregoriou, O ;

Vitoratos, N ;

Papadias, C ;

Konidaris, S ;

Gargaropoulos, A ;

Rizos, D .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1996, 64 (02) :213-216

← 1 2 →