Discovery of TAK-137 and TAK-653, clinical candidates of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiators with reduced agonistic activities

被引:0
|
作者
Nakamura, Shinji [1 ]
Toyofuku, Masashi [1 ]
Honda, Eiji [1 ]
Imaeda, Toshihiro [1 ]
Yokota, Akihiro [1 ]
Sogabe, Satoshi [1 ]
Kunugi, Akiyoshi [1 ]
Kuno, Haruhiko [1 ]
Kosugi, Yohei [1 ]
Kori, Masakuni [1 ]
Miki, Takashi [1 ]
Kimura, Haruhide [1 ]
Kuroita, Takanobu [1 ]
Kaku, Tomohiro [1 ]
机构
[1] Takeda Pharmaceut Co Ltd, Fujisawa, Kanagawa, Japan
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
314
引用
收藏
页数:1
相关论文
共 50 条
  • [31] 5-HT1 and 5-HT2 receptor agonists blunt (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats
    Pinilla, L
    Gonzalez, LC
    Tena-Sempere, M
    Aguilar, E
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2001, 144 (05) : 535 - 541
  • [32] Estrogen dissociates Tau and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit in postischemic hippocampus
    Cardona-Gomez, Gloria Patricia
    Arango-Davila, Cesar
    Gallego-Gomez, Juan Carlos
    Barrera-Ocampo, Alvaro
    Pimienta, Hernan
    Garcia-Segura, Luis Miguel
    NEUROREPORT, 2006, 17 (12) : 1337 - 1341
  • [33] YM872, a novel selective α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats
    Takahashi, M
    Ni, JW
    Kawasaki-Yatsugi, S
    Toya, T
    Yatsugi, SI
    Shimizu-Sasamata, M
    Koshiya, K
    Shishikura, JI
    Sakamoto, S
    Yamaguchi, T
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1998, 284 (02): : 467 - 473
  • [34] Application of biocatalysis to drug metabolism:: Preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis
    Zmijewski, Milton
    Gillespie, Todd A.
    Jackson, David A.
    Schmidt, Douglas F.
    Yi, Ping
    Kulanthaivel, Palaniappan
    DRUG METABOLISM AND DISPOSITION, 2006, 34 (06) : 925 - 931
  • [35] THE ORGANIZATION OF THE GENE FOR THE FUNCTIONALLY DOMINANT ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTOR SUBUNIT GLUR-B
    KOHLER, M
    KORNAU, HC
    SEEBURG, PH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (26) : 17367 - 17370
  • [36] Supraspinal and spinal α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and N-methyl-D-aspartate glutamatergic control of the micturition reflex in the urethane-anesthetized rat
    Yoshiyama, M
    De Groat, WC
    NEUROSCIENCE, 2005, 132 (04) : 1017 - 1026
  • [37] Discovery and Characterization of a Novel Dihydroisoxazole Class of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
    Patel, Nandini C.
    Schwarz, Jacob
    Hou, Xinjun J.
    Hoover, Dennis J.
    Xie, Longfei
    Fliri, Anton J.
    Gallaschun, Randall J.
    Lazzaro, John T.
    Bryce, Dianne K.
    Hoffmann, William E.
    Hanks, Ashley N.
    McGinnis, Dina
    Marr, Eric S.
    Gazard, Justin L.
    Hajos, Mihaly
    Scialis, Renato J.
    Hurst, Raymond S.
    Shaffer, Christopher L.
    Pandit, Jayvardhan
    O'Donnell, Christopher J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (22) : 9180 - 9191
  • [38] ACTIVATION OF GROUP I METABOTROPIC GLUTAMATE RECEPTORS INCREASES SERINE PHOSPHORYLATION OF GLUR1 α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTORS IN THE RAT DORSAL STRIATUM
    Ahn, S. M.
    Seo, S. Y.
    Choe, E. S.
    JOURNAL OF NEUROCHEMISTRY, 2010, 115 : 71 - 71
  • [39] Activation of Group I Metabotropic Glutamate Receptors Increases Serine Phosphorylation of GluR1 α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptors in the Rat Dorsal Striatum
    Ahn, Sung Min
    Choe, Eun Sang
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 329 (03): : 1117 - 1126
  • [40] ALPHA-[H-3]AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID BINDING TO HUMAN CEREBRAL CORTICAL MEMBRANES - MINIMAL CHANGES IN POSTMORTEM BRAINS OF CHRONIC-SCHIZOPHRENICS
    KURUMAJI, A
    ISHIMARU, M
    TORU, M
    JOURNAL OF NEUROCHEMISTRY, 1992, 59 (03) : 829 - 837