Palladium-catalyzed α-vinylation of carbonyl compounds

被引：74

作者：

Huang, Jinkun ^{[1
]}

Bunel, Emilio ^{[1
]}

Faul, Margaret M. ^{[1
]}

机构：

[1] Chem Proc R&D, Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 21期

关键词：

D O I：

10.1021/ol7019839

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, general, catalytic system for the alpha-vinylation of carbonyl compounds has been developed. By employing [Pd((PBu3)-Bu-t)Br](2) as Catalyst and LHMDS as base, vinyl bromides, vinyl triflates, and vinyl tosylates couple with 3-methyloxindole in satisfactory yields. The same catalytic system is extended to the alpha-vinylation of ketones and esters.

引用

页码：4343 / 4346

页数：4

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