Mitochondrial DNA content and oxidation in bipolar disorder and its role across brain regions

被引：19

作者：

Bodenstein, D. F. ^{[1
]}

Kim, H. K. ^{[1
]}

Brown, N. C. ^{[1
]}

Navaid, B. ^{[1
]}

Young, L. T. ^{[1
,2
,3
]}

Andreazza, A. C. ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[3] Ctr Addict & Mental Hlth, Toronto, ON, Canada

来源：

NPJ SCHIZOPHRENIA | 2019年 / 5卷 / 1期

关键词：

POSTMORTEM FRONTAL-CORTEX; PREFRONTAL CORTEX; COMMON DELETION; QUANTITATIVE-ANALYSIS; DOPAMINE; STRESS; SCHIZOPHRENIA; EXPRESSION; CEREBELLUM; NUMBER;

D O I：

10.1038/s41537-019-0089-5

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The underlying pathology of bipolar disorder remains unknown, though evidence is accumulating to support a role of mitochondrial dysfunction. In this study, we aim to investigate electron transport chain complex I subunit NDUFS7 protein expression; mtDNA content; common deletion; and oxidation in the Broadmann area 24 (BA24), cerebellum, hippocampus, and prefrontal cortex from patients with bipolar disorder, schizophrenia, and non-psychiatric controls. Here, we demonstrate no changes in NDUFS7 in BA24, cerebellum or hippocampus, increases in mtDNA content in hippocampus of patients with bipolar disorder, and decreases in mtDNA oxidation in patients with bipolar disorder and schizophrenia, respectively. Paired analysis between BA24 and cerebellum reveal increases within NDUFS7 levels and mtONA content in cerebellum of patients with bipolar disorder or schizophrenia. We found a positive correlation between NDUFS7 and mtDNA content (ND4 and ND5) when combining brain regions. Our study supports the involvement of mitochondrial dysfunction in bipolar disorder and schizophrenia.

引用

页数：8

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