Prevalence and Prognosis of Mild Anemia in Non-Dialysis Chronic Kidney Disease: A Prospective Cohort Study in Outpatient Renal Clinics

被引：29

作者：

De Nicola, Luca ^{[1
,2
,7
]}

Minutolo, Roberto ^{[2
,7
]}

Chiodini, Paolo ^{[2
]}

Zamboli, Pasquale ^{[2
,7
]}

Cianciaruso, Bruno ^{[3
]}

Nappi, Felice ^{[4
,10
]}

Signoriello, Simona ^{[2
]}

Conte, Giuseppe ^{[2
,7
]}

Zoccali, Carmine ^{[5
,6
,28
]}

Iodice, F. C. ^{[7
]}

Borrelli, S. ^{[7
]}

Scigliano, R. ^{[7
]}

Gallo, C. ^{[7
]}

Materiale, T. ^{[8
]}

Minale, B. ^{[8
]}

Paglionico, C. ^{[8
]}

Pota, A. ^{[9
]}

Andreucci, V. E. ^{[9
]}

Avella, F. ^{[10
]}

Di Iorio, B. R. ^{[11
]}

Bellizzi, V. ^{[11
]}

Cestaro, R. ^{[12
]}

Martignetti, V. ^{[13
]}

Morrone, L. ^{[13
]}

Lupo, A. ^{[14
]}

Abaterusso, C. ^{[14
]}

Donadio, C. ^{[15
]}

Bonomini, M. ^{[16
]}

Sirolli, V. ^{[16
]}

Casino, F. ^{[17
]}

Lopez, T. ^{[17
]}

Detomaso, F. ^{[18
]}

Giannattasio, M. ^{[18
]}

Virgilio, M. ^{[19
]}

Tarantino, G. ^{[19
]}

Cristofano, C.

Tuccillo, S. ^{[20
]}

Chimienti, S. ^{[20
]}

Petrarulo, F. ^{[21
]}

Giancaspro, V. ^{[21
]}

Strippoli, M. ^{[22
]}

Laraia, E. ^{[23
]}

Gallucci, M. ^{[24
]}

Gigante, B. ^{[24
]}

Lodeserto, C. ^{[25
]}

Santese, D. ^{[25
]}

Montanaro, A. ^{[26
]}

Giordano, R. ^{[26
]}

Caglioti, A. ^{[27
]}

Fuiano, G. ^{[27
]}

机构：

[1] Univ Naples 2, Dipartimento Gerontol, Cattedra Nefrol, IT-80131 Naples, Italy

[2] Univ Naples 2, Chair Biostat, IT-80131 Naples, Italy

[3] Univ Federico II, Div Nephrol, Naples, Italy

[4] County Hosp, Div Nephrol, Nola, Italy

[5] United Hosp, Renal Hypertens & Transplant Unit, Div Nephrol, Reggio Di Calabria, Italy

[6] CNR IBIM, Div Nephrol, Reggio Di Calabria, Italy

[7] Univ Naples 2, Med Sch, Naples, Italy

[8] Napoli ASL NA 1, Naples, Italy

[9] Univ Naples Federico II, Med Sch, Naples, Italy

[10] Nola Hosp, Nola, Italy

[11] Solofra Hosp, Solofra, Italy

[12] Sapri Hosp, Sapri, Italy

[13] Benevento Hosp, Benevento, Italy

[14] Verona Univ, Med Sch, Verona, Italy

[15] Pisa Univ, Med Sch, Pisa, Italy

[16] Chieti Univ, Med Sch, Chieti, Italy

[17] Matera Hosp, Matera, Italy

[18] Putignano Hosp, Putignano, Italy

[19] Molfetta Hosp, Molfetta, Italy

[20] Manduria Hosp, Manduria, Italy

[21] Bari Di Venere Hosp, Bari, Italy

[22] Bari Univ, Med Sch, Bari, Italy

[23] Bari S Rita Hosp, Bari, Italy

[24] Galatina Hosp, Galatina, Italy

[25] Taranto Hosp, Taranto, Italy

[26] Martina Franca Hosp, Martina Franca, Italy

[27] Catanzaro Univ, Med Sch, Catanzaro, Italy

[28] Reggio Calabria CNR, Reggio Di Calabria, Italy

[29] Messina Hosp, Messina, Italy

[30] Univ Messina, Med Sch, Messina, Italy

[31] Catania Univ, Med Sch, Catania, Italy

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2010年 / 32卷 / 06期

关键词：

Anemia; Hemoglobin; Chronic kidney disease; End-stage renal disease; Survival; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; ASSOCIATION; HEART; PROGRESSION; HEMOGLOBIN; MORTALITY;

D O I：

10.1159/000321468

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: We evaluated prevalence and prognosis of mild anemia, defined as Hb (g/dl) 11-13.5 in males and 11-12 in females, in a prospective cohort of stage 3-5 chronic kidney disease (CKD) patients. Methods: We enrolled 668 consecutive patients in 25 renal clinics during 2003. Patients with frank anemia (Hb <11 or erythropoiesis-stimulating agents) at enrolment were excluded. Mild anemia was evaluated at two visits planned with an interval of 18 +/- 6 months to identify four categories: no anemia at both visits, mild anemia at visit 1 resolving at visit 2 (RES), mild anemia persisting at both visits (PER), and progression from no anemia or mild anemia at visit 1 to mild or frank anemia at visit 2 (PRO). Results: Mild anemia was present in 41.3% at visit 1 and 34.1% at visit 2. We identified PER in 22% patients, RES in 10%, and PRO in 26%. In the subsequent 40 months, 125 patients developed end-stage renal disease (ESRD) and 94 died. At competing risk model, PER predicted ESRD (hazard ratio, HR, 1.82, 95% confidence interval, Cl, 1.01-3.29) while PRO predicted both ESRD (HR 1.81, 95% Cl 1.02-3.23) and death (HR 1.87,95% CI1.04-3.37). Conclusion: In non-dialysis chronic kidney disease, mild anemia is prevalent and it is a marker of risk excess when persistent or progressive over time. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：533 / 540

页数：8

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