BDNF Va166Met polymorphism is associated with aggressive behavior in schizophrenia

被引：57

作者：

Spalletta, G. ^{[1
]}

Morris, D. W. ^{[2
]}

Angelucci, F. ^{[1
]}

Rubino, I. A. ^{[3
]}

Spoletini, I. ^{[1
]}

Bria, P. ^{[4
]}

Martinotti, G. ^{[4
]}

Siracusano, A. ^{[3
]}

Bonaviri, G. ^{[5
]}

Bernardini, S. ^{[6
]}

Caltagirone, C. ^{[1
]}

Bossu, P. ^{[1
]}

Donohoe, G. ^{[2
]}

Gill, M. ^{[2
]}

Corvin, A. P. ^{[2
]}

机构：

[1] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, I-00179 Rome, Italy

[2] Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 2, Ireland

[3] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy

[4] Catholic Univ, Inst Psychiat, Rome, Italy

[5] Sapienza Univ, Dept Neurol, Rome, Italy

[6] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy

来源：

EUROPEAN PSYCHIATRY | 2010年 / 25卷 / 06期

关键词：

BDNF; Va166Met; Polymorphism; Aggression; Schizophrenia; NEUROTROPHIC FACTOR GENE; VAL66MET POLYMORPHISM; HUMAN-MEMORY; DISORDER; SERUM;

D O I：

10.1016/j.eurpsy.2009.10.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Va166Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：311 / 313

页数：3

共 20 条

[1] BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F
Brenè, S
Mathé, AA
[J]. MOLECULAR PSYCHIATRY, 2005, 10 (04) : 345 - 352
[2] Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O
McClung, CA
DiLeone, RJ
Krishnan, V
Renthal, W
Russo, SJ
Graham, D
Tsankova, NM
Bolanos, CA
Rios, M
Monteggia, LM
Self, DW
Nestler, EJ
[J]. SCIENCE, 2006, 311 (5762) : 864 - 868
[3] Characterization of single-nucleotide polymorphisms in coding regions of human genes
Cargill, M
Altshuler, D
Ireland, J
Sklar, P
Ardlie, K
Patil, N
Lane, CR
Lim, EP
Kalyanaraman, N
Nemesh, J
Ziaugra, L
Friedland, L
Rolfe, A
Warrington, J
Lipshutz, R
Daley, GQ
Lander, ES
[J]. NATURE GENETICS, 1999, 22 (03) : 231 - 238
[4] Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice
Chan, J. P.
Unger, T. J.
Byrnesa, J.
Rios, M.
[J]. NEUROSCIENCE, 2006, 142 (01) : 49 - 58
[5] Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses
Durany, N
Michel, T
Zöchling, R
Boissl, KW
Cruz-Sánchez, FF
Riederer, P
Thome, J
[J]. SCHIZOPHRENIA RESEARCH, 2001, 52 (1-2) : 79 - 86
[6] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Egan, MF
Kojima, M
Callicott, JH
Goldberg, TE
Kolachana, BS
Bertolino, A
Zaitsev, E
Gold, B
Goldman, D
Dean, M
Lu, B
Weinberger, DR
[J]. CELL, 2003, 112 (02) : 257 - 269
[7] Association study of the brain-derived neurotrophic factor gene and childhood aggression
Guerin, Andrea A.
Beitchman, Joseph H.
Strauss, John
Kennedy, James L.
[J]. PSYCHIATRIC GENETICS, 2007, 17 (01) : 7 - 8
[8] Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
Hariri, AR
Goldberg, TE
Mattay, VS
Kolachana, BS
Callicott, JH
Egan, MF
Weinberger, DR
[J]. JOURNAL OF NEUROSCIENCE, 2003, 23 (17) : 6690 - 6694
[9] PROFILES OF AGGRESSION AMONG PSYCHIATRIC-PATIENTS .1. NATURE AND PREVALENCE
KAY, SR
WOLKENFELD, F
MURRILL, LM
[J]. JOURNAL OF NERVOUS AND MENTAL DISEASE, 1988, 176 (09) : 539 - 546
[10] THE POSITIVE AND NEGATIVE SYNDROME SCALE (PANSS) FOR SCHIZOPHRENIA
KAY, SR
FISZBEIN, A
OPLER, LA
[J]. SCHIZOPHRENIA BULLETIN, 1987, 13 (02) : 261 - 276

← 1 2 →