Thymosin α1 -: A historical overview

被引：28

作者：

Garaci, Enrico ^{[1
]}

机构：

[1] Ist Super Sanita, I-00161 Rome, Italy

来源：

THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM | 2007年 / 1112卷

关键词：

thymosin alpha 1; combination therapies;

D O I：

10.1196/annals.1415.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymosin alpha 1 (T alpha 1), initially isolated from thymus, was characterized by Allan Goldstein in 1977. Since the beginning, our studies were aimed at evaluating its immunomodulating effects when used in combination with cytokines and chemotherapy. Combination therapies have now proved to be effective in inhibiting tumoral growth and in controlling infective diseases especially in the immunocompromised host. More recent studies showed that Tot 1 molecule increased major histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role. Overall these results led us to start pilot clinical trials on patients with hepatitis C and cancer.

引用

页码：14 / 20

页数：7

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