Hyaluronan chain conformation and dynamics

被引：44
作者：
Furlan, S
La Penna, G
Perico, A
Cesàro, A
机构：
[1] Univ Trieste, Dept Biochem Biophys & Macromol Chem, UdR INSTM, I-34127 Trieste, Italy
[2] CNR, Sect Genova, Inst Macromol Studies, I-16149 Genoa, Italy
来源：
CARBOHYDRATE RESEARCH | 2005年 / 340卷 / 05期
关键词：
hyaluronan; HA oligomers; Monte Carlo; conformational energy; local dynamics; chain conformation;
D O I：
10.1016/j.carres.2005.01.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An overview of the present state of research in the field of hyaluronan chain conformational aspects is presented. The relationship between structure and dynamics are illustrated for a series of hyaluronan oligomers. Conformational characteristics of hyaluronan chains are discussed, together with the dynamic chain patterns, evaluated by using a theoretical approach to diffusive polymer dynamics. The dependence of correlation times and NMR relaxation parameters from the chain dimension are investigated. Topological features and dimensional properties are related to the structural determinants by using classical computational methods of molecular mechanics and Monte Carlo simulation. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：959 / 970
页数：12
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