Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences

被引：108

作者：

Mani, Ram-Shankar ^{[1
,3
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Michigan, Michigan Ctr Translat Pathol, Sch Med, Ann Arbor, MI 48109 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Urol, Sch Med, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 12期

关键词：

CYTIDINE DEAMINASE AID; CLASS SWITCH RECOMBINATION; COMMON FRAGILE SITES; DOUBLE-STRAND BREAKS; GENE FUSIONS; CHROMOSOMAL TRANSLOCATIONS; RET PROTOONCOGENE; HOMOLOGOUS RECOMBINATION; OXYGEN-METABOLISM; SPATIAL PROXIMITY;

D O I：

10.1038/nrg2883

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom, cell type-, cell stage- and locus-specific events. Recent studies have revealed novel cellular mechanisms and environmental cues that influence genomic rearrangements. In this Review, we consider the multitude of influences on genomic rearrangements by grouping these influences into four categories: proximity of chromosomal regions in the nucleus, cellular stress, inappropriate DNA repair or recombination, and DNA sequence and chromatin features. The synergy of these triggers can poise a cell for rearrangements and here we aim to provide a conceptual framework for understanding the genesis of genomic rearrangements.

引用

页码：819 / 829

页数：11

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