Despite extensive research, the pathophysiology of Charcot foot is still not fully understood. In the case of late diagnosis and insufficient therapy, severe deformity may occur. Different theories on the pathophysiology of the Charcot foot are presented and discussed. This article presents different theories on the pathophysiology of the Charcot foot and presents studies on the cellular, immunological, and bone metabolism level. One theory is based on repetitive microtraumas in the sensoric deficient foot which lead to development of Charcot foot. Another theory is based on pathologic neurovascular innervation leading to morphologic changes. Probably both mechanisms are responsible in combination as etiological factors inducing neuropathy A combination of mechanical, vascular, and biologic factors induce the neuropathic foot and result in severe deformity if diagnosis is too late.
机构:
So Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ 85723 USASo Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ 85723 USA
Armstrong, DG
Peters, EJG
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机构:
So Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ 85723 USASo Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ 85723 USA
机构:
St Michaels Hosp, Toronto, ON, Canada
Univ Calgary, Div Orthopaed Surg, Calgary, AB, CanadaSt Michaels Hosp, Toronto, ON, Canada
Dodd, Andrew
Daniels, Timothy R.
论文数: 0引用数: 0
h-index: 0
机构:
St Michaels Hosp, Toronto, ON, Canada
St Michaels Hosp, Div Orthopaed Surg, Toronto, ON, Canada
Univ Toronto, Toronto, ON, CanadaSt Michaels Hosp, Toronto, ON, Canada
Daniels, Timothy R.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME,
2018,
100
(08):
: 696
-
711