Synthesis of heterofunctional 3,3'-sulfonyldibenzoic acid derivatives

被引：0

作者：

Vasilevskii, Dmitrii A. ^{[1
]}

Yashchenko, Vladimir S. ^{[1
]}

Ol'khovik, Vyacheslav K. ^{[1
]}

机构：

[1] Natl Acad Sci Belarus, Inst Chem New Mat, 36 Fr Skaryna St, Minsk 220141, BELARUS

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 02期

关键词：

RECEPTOR ANTAGONISTS; DIARYL SULFONES; INHIBITORS; DIARYLSULFONES; SULFONYLATION; DISCOVERY; DESIGN;

D O I：

10.1007/s10593-016-1844-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the preparation of previously difficult to access heterofunctional 3,3'-sulfonyldibenzoic acid derivatives containing amino-, alkylamino-, hydroxy-, and alkoxy substituents at the vicinal position relative to the sulfonyl group has been elaborated. The interaction of methyl 4-nitro-10,10-dioxophenoxathiine-2,8-dicarboxylate with amines and O-nucleophiles was shown to proceed under mild conditions, resulting in oxathiine ring opening, and the nucleophilic substitution occurred exclusively at position 4D degrees of phenoxathiine.

引用

页码：128 / 132

页数：5

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