Synthesis of heterofunctional 3,3'-sulfonyldibenzoic acid derivatives

被引：0
|
作者：
Vasilevskii, Dmitrii A. [1 ]
Yashchenko, Vladimir S. [1 ]
Ol'khovik, Vyacheslav K. [1 ]
机构：
[1] Natl Acad Sci Belarus, Inst Chem New Mat, 36 Fr Skaryna St, Minsk 220141, BELARUS
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 02期
关键词：
RECEPTOR ANTAGONISTS; DIARYL SULFONES; INHIBITORS; DIARYLSULFONES; SULFONYLATION; DISCOVERY; DESIGN;
D O I：
10.1007/s10593-016-1844-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the preparation of previously difficult to access heterofunctional 3,3'-sulfonyldibenzoic acid derivatives containing amino-, alkylamino-, hydroxy-, and alkoxy substituents at the vicinal position relative to the sulfonyl group has been elaborated. The interaction of methyl 4-nitro-10,10-dioxophenoxathiine-2,8-dicarboxylate with amines and O-nucleophiles was shown to proceed under mild conditions, resulting in oxathiine ring opening, and the nucleophilic substitution occurred exclusively at position 4D degrees of phenoxathiine.
引用
收藏
页码：128 / 132
页数：5
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