GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility

被引：6

作者：

Torrens-Mas, Margalida ^{[1
]}

Perello-Reus, Catalina M. ^{[2
]}

Trias-Ferrer, Neus ^{[1
]}

Ibargueen-Gonzalez, Lesly ^{[2
]}

Crespi, Catalina ^{[3
]}

Galmes-Panades, Aina Maria ^{[1
,4
]}

Navas-Enamorado, Cayetano ^{[1
]}

Sanchez-Polo, Andres ^{[1
]}

Pierola-Lopetegui, Javier ^{[5
]}

Masmiquel, Luis ^{[6
]}

Crespi, Lorenzo Socias ^{[7
]}

Barcelo, Carles ^{[2
]}

Gonzalez-Freire, Marta ^{[1
]}

机构：

[1] Hlth Res Inst Balear Isl IdISBa, Translat Res Aging & Longev Grp TRIAL Grp, Palma De Mallorca, Spain

[2] Hlth Res Inst Balear Isl IdISBa, Translat Pancreat Canc Oncogenesis Grp, Palma De Mallorca, Spain

[3] Hlth Res Inst Balear Isl IdISBa, Cell Culture & Flow Cytometry Facil, Palma De Mallorca, Spain

[4] Univ Balear Isl, Inst Educ Res & Innovat IRIE, Phys Act & Sport Sci Res Grp GICAFE, Palma De Mallorca, Spain

[5] Hlth Res Inst Balear Isl IdISBa, Microscopy Facil, Palma De Mallorca, Spain

[6] Hlth Res Inst Balear Isl IdISBa, Vasc & Metab Pathol Grp, Palma De Mallorca, Spain

[7] Son Llatzer Univ Hosp, Hlth Res Inst Balear Isl IdISBa, Intens Care Unit, Palma De Mallorca, Spain

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷

基金：

英国科研创新办公室;

关键词：

GDF5; ACE2; inflammation; mutations; COVID-19; CONVERTING ENZYME 2; EXPRESSION; RISK;

D O I：

10.3389/fcimb.2022.942951

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and uninfected control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility.

引用

页数：21

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