FeCl3 mediated dimerization of dihydropyrrolo[2,1-a]isoquinolines and chlorination of tetrasubstituted pyrroles

被引:26
作者
Jiang, Xue-Fei [1 ]
Tan, Hao [1 ]
Cui, Hai-Lei [1 ]
机构
[1] Chongqing Univ Arts & Sci, Lab Asymmetr Synth, 319 Honghe Ave, Chongqing 402160, Peoples R China
基金
中国国家自然科学基金;
关键词
COUPLING REACTION; OXIDATIVE DIMERIZATION; RADICAL CATIONS; INDOLES; DERIVATIVES; THIOPHENES; INDOLIZINES; EFFICIENT; LAMELLARINS; CYCLIZATION;
D O I
10.1039/c9ob02607j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We have developed a mild and direct dimerization of dihydropyrrolo[2,1-a]isoquinolines through FeCl3-mediated oxidative homocoupling. A series of dimeric dihydropyrroloisoquinoline derivatives were obtained in acceptable to excellent yields (up to >99%). Attempts to expand this dimerization system to the synthesis of dimeric pyrroles failed and chlorination products were obtained in most cases instead of dimeric pyrroles.
引用
收藏
页码:660 / 665
页数:6
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