FeCl3 mediated dimerization of dihydropyrrolo[2,1-a]isoquinolines and chlorination of tetrasubstituted pyrroles

被引：26

作者：

Jiang, Xue-Fei ^{[1
]}

Tan, Hao ^{[1
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Lab Asymmetr Synth, 319 Honghe Ave, Chongqing 402160, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

COUPLING REACTION; OXIDATIVE DIMERIZATION; RADICAL CATIONS; INDOLES; DERIVATIVES; THIOPHENES; INDOLIZINES; EFFICIENT; LAMELLARINS; CYCLIZATION;

D O I：

10.1039/c9ob02607j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a mild and direct dimerization of dihydropyrrolo[2,1-a]isoquinolines through FeCl3-mediated oxidative homocoupling. A series of dimeric dihydropyrroloisoquinoline derivatives were obtained in acceptable to excellent yields (up to >99%). Attempts to expand this dimerization system to the synthesis of dimeric pyrroles failed and chlorination products were obtained in most cases instead of dimeric pyrroles.

引用

页码：660 / 665

页数：6

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