Acute myeloid leukemia: How to treat the fit patient over age 75?

被引：5

作者：

Luger, Selina M. ^{[1
]}

机构：

[1] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Leukemia Program, 3400 Civ Ctr Blvd,12th Floor South Pavil, Philadelphia, PA 19104 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2019年 / 32卷 / 04期

关键词：

Acute myeloid leukemia; AML; Elderly; Glasdegib; Venetoclax; INTENSIVE CHEMOTHERAPY; ELDERLY-PATIENTS; OLDER PATIENTS; EARLY DEATH; AZACITIDINE; THERAPY; PREDICTION; SURVIVAL; CARE; TOOL;

D O I：

10.1016/j.beha.2019.101105

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Survival rates for patients with acute myeloid leukemia (AML) older than 75 years are still quite dismal. Recent approvals, therefore, of two agents specifically to treat older patients-glasdegib and venetoclax-have created excitement among the medical community. Clinical data, particularly complete response (CR) rates and CR with incomplete hematologic recovery (CRi), look quite promising and are reviewed here. Yet the question remains whether fit elderly patients should receive combination therapy containing the newer agents, particularly since intensive chemotherapy remains the only treatment that has demonstrated the ability to achieve long-term disease-free survival.

引用

页数：5

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