Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems

被引：42

作者：

Pardridge, WM ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

来源：

DRUG TRANSPORT(ERS) AND THE DISEASED BRAIN | 2005年 / 1277卷

关键词：

blood-brain barrier; insulin receptor; transcytosis; RNA interference; FIBROBLAST-GROWTH-FACTOR; NEUROTROPHIC FACTOR; INTRAVENOUS-INJECTION; IN-VIVO; DELIVERY; ISCHEMIA; RADIOPHARMACEUTICALS; NEUROPROTECTION; CONJUGATION; EXPRESSION;

D O I：

10.1016/j.ics.2005.02.011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The delivery of recombinant proteins, peptides, antisense agents, and non-viral gene medicines to brain via a trans-vascular route following intravenous administration is possible with the development of blood brain barrier drug targeting technology. Drugs or genes are reformulated and attached to molecular Trojan horses that ferry the drug or gene into brain via receptor-mediated transport across the BBB on endogenous peptide transport systems. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：49 / 62

页数：14

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