Toxicity Thresholds for Diclofenac, Acetaminophen and Ibuprofen in the Water Flea Daphnia magna

被引：84
作者：
Du, Juan [1 ,2 ]
Mei, Cheng-Fang [1 ,2 ]
Ying, Guang-Guo [3 ]
Xu, Mei-Ying [1 ,2 ]
机构：
[1] Guangdong Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou, Guangdong, Peoples R China
[2] State Key Lab Appl Microbiol Southern China, Guangzhou, Guangdong, Peoples R China
[3] Chinese Acad Sci, Guangzhou Inst Geochem, Guangzhou, Guangdong, Peoples R China
来源：
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2016年 / 97卷 / 01期
基金：
美国国家科学基金会;
关键词：
Non-steroid anti-inflammatory drugs; Daphnia magna; Acute toxicity; Chronic toxicity; Toxicity threshold; SOLID-PHASE EXTRACTION; MASS-SPECTROMETRY; PHARMACEUTICALS; ACID; EFFLUENT; CONTAMINANTS; EXPOSURE; FISH;
D O I：
10.1007/s00128-016-1806-7
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Non-steroid anti-inflammatory drugs (NSAIDs) have been frequently detected in aquatic ecosystem and posed a huge risk to non-target organisms. The aim of this study was to evaluate the toxic effects of three typical NSAIDs, diclofenac (DFC), acetaminophen (APAP) and ibuprofen (IBP), toward the water flea Daphnia magna. All three NSAIDs showed remarkable time-dependent and concentration-dependent effects on D. magna, with DFC the highest and APAP the lowest toxic. Survival, growth and reproduction data of D. magna from all bioassays were used to determine the LC10 and LC50 (10 % lethal and median lethal concentrations) values of NSAIDs, as well as the EC10 and EC50 (10 % effect and median effect concentrations) values. Concentrations for the lethal and sublethal toxicity endpoints were mainly in the low ppm-range, of which reproduction was the most sensitive one, indicating that non-target organisms might be adversely affected by relevant ambient low-level concentrations of NSAIDs after long-time exposures.
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页码：84 / 90
页数：7
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