Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression

被引：40

作者：

Mannavola, Francesco ^{[1
]}

D'Oronzo, Stella ^{[1
,2
]}

Cives, Mauro ^{[1
]}

Stucci, Luigia Stefania ^{[1
]}

Ranieri, Girolamo ^{[2
]}

Silvestris, Franco ^{[1
]}

Tucci, Marco ^{[1
,2
]}

机构：

[1] Univ Bari Aldo Moro, Dept Biomed Sci & Clin Oncol, I-70121 Bari, Italy

[2] Natl Canc Res Ctr, Ist Tumori Giovanni Paolo 2, I-70121 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 01期

关键词：

melanoma; extracellular vesicles; epigenetic modifications; miRNAs; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-DERIVED EXOSOMES; TUMOR PROGRESSION; MACROH2A SUPPRESSES; CUTANEOUS MELANOMA; MICROVESICLES; METHYLATION; INHIBITION; EXPRESSION;

D O I：

10.3390/ijms21010052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cutaneous melanoma shows a high metastatic potential based on its ability to overcome the immune system's control. The mechanisms activated for these functions vary extremely and are also represented by the production of a number of extracellular vesicles including exosomes. Other vesicles showing a potential role in the melanoma progression include oncosomes and melanosomes and the majority of them mediate tumor processes including angiogenesis, immune regulation, and modifications of the micro-environment. Moreover, a number of epigenetic modifications have been described in melanoma and abundant production of altered microRNAs (mi-RNAs), non-coding RNAs, histones, and abnormal DNA methylation have been associated with different phases of melanoma progression. In addition, exosomes, miRNAs, and other molecular factors have been used as potential biomarkers reflecting disease evolution while others have been suggested to be potential druggable molecules for therapeutic application.

引用

页数：16

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