Synthesis of enantiomers of N-(2-aminopurin-6-yl) amino acids

被引：9

作者：

Krasnov, V. P. ^{[1
]}

Vigorov, A. Yu. ^{[1
]}

Gruzdev, D. A. ^{[1
]}

Levit, G. L. ^{[1
]}

Demin, A. M. ^{[1
]}

Nizova, I. A. ^{[1
]}

Tumashov, A. A. ^{[1
]}

Sadretdinova, L. Sh. ^{[1
]}

Gorbunov, E. B. ^{[1
]}

Charushin, V. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, 22-20 Ul S Kovalevskoi, Ekaterinburg 620137, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

purines; amino acids; enantiomers; racemization; high performance liquid chromatography; BIOLOGICAL-ACTIVITY; PURINE DERIVATIVES; NUCLEOSIDE ANALOGS; PRODRUGS; KINASE; AGENTS; TRANSPORTER; INHIBITORS; ADENOSINE; DELIVERY;

D O I：

10.1007/s11172-015-1125-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nonracemic N-(2-aminopurin-6-yl)-substituted amino acids were synthesized by nucleophilic substitution of chlorine atom in 2-acetamido-6-chloropurine upon treatment with amino acid tert-butyl esters and subsequent removal of protecting groups. Their enantiomeric composition was determined by HPLC on chiral stationary phases.

引用

页码：2106 / 2113

页数：8

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