Cooperation of signalling pathways in embryonic mammary gland development

被引：94
作者：
Robinson, Gertraud W. [1 ]
机构：
[1] NIH, NIDDKD, Lab Genet & Physiol, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS GENETICS | 2007年 / 8卷 / 12期
关键词：
D O I：
10.1038/nrg2227
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
引用
收藏
页码：963 / 972
页数：10
相关论文
共 54 条
  • [41] Identification of signaling pathways in early mammary gland development by mouse genetics
    Robinson, GW
    [J]. BREAST CANCER RESEARCH, 2004, 6 (03): : 105 - 108
  • [42] Regulation of mammary gland development by tissue interaction
    Robinson, GW
    Karpf, ABC
    Kratochwil, K
    [J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1999, 4 (01) : 9 - 19
  • [43] ROBINSON GW, 2000, METHODS MAMMARY GLAN, P307
  • [44] Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    Satokata, I
    Ma, L
    Ohshima, H
    Bei, M
    Woo, I
    Nishizawa, K
    Maeda, T
    Takano, Y
    Uchiyama, M
    Heaney, S
    Peters, H
    Tang, ZQ
    Maxson, R
    Maas, R
    [J]. NATURE GENETICS, 2000, 24 (04) : 391 - 395
  • [45] Generation of a functional mammary gland from a single stem cell
    Shackleton, M
    Vaillant, F
    Simpson, KJ
    Stingl, J
    Smyth, GK
    Asselin-Labat, ML
    Wu, L
    Lindeman, GJ
    Visvader, JE
    [J]. NATURE, 2006, 439 (7072) : 84 - 88
  • [46] Purification and unique properties of mammary epithelial stem cells
    Stingl, J
    Eirew, P
    Ricketson, I
    Shackleton, M
    Vaillant, F
    Choi, D
    Li, HYI
    Eaves, CJ
    [J]. NATURE, 2006, 439 (7079) : 993 - 997
  • [47] Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development
    Tümpel, S
    Sanz-Ezquerro, JJ
    Isaac, A
    Eblaghie, MC
    Dobson, J
    Tickle, C
    [J]. DEVELOPMENTAL BIOLOGY, 2002, 250 (02) : 251 - 262
  • [48] DEVELOPMENT OF SEVERAL ORGANS THAT REQUIRE INDUCTIVE EPITHELIAL-MESENCHYMAL INTERACTIONS IS IMPAIRED IN LEF-1-DEFICIENT MICE
    VANGENDEREN, C
    OKAMURA, RM
    FARINAS, I
    QUO, RG
    PARSLOW, TG
    BRUHN, L
    GROSSCHEDL, R
    [J]. GENES & DEVELOPMENT, 1994, 8 (22) : 2691 - 2703
  • [49] Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Veltmaat, Jacqueline M.
    Relaix, Frederic
    Le, Lendy T.
    Kratochwil, Klaus
    Sala, Frederic G.
    van Veelen, Wendy
    Rice, Ritva
    Spencer-Dene, Bradley
    Mailleux, Arnaud A.
    Rice, David P.
    Thiery, Jean Paul
    Bellusci, Saverio
    [J]. DEVELOPMENT, 2006, 133 (12): : 2325 - 2335
  • [50] Identification of the mammary line in mouse by Wnt10b expression
    Veltmaat, JM
    Van Veelen, W
    Thiery, JP
    Bellusci, S
    [J]. DEVELOPMENTAL DYNAMICS, 2004, 229 (02) : 349 - 356
123456