Cooperation of signalling pathways in embryonic mammary gland development

被引：94
作者：
Robinson, Gertraud W. [1 ]
机构：
[1] NIH, NIDDKD, Lab Genet & Physiol, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS GENETICS | 2007年 / 8卷 / 12期
关键词：
D O I：
10.1038/nrg2227
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
引用
收藏
页码：963 / 972
页数：10
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