Cooperation of signalling pathways in embryonic mammary gland development

被引：94
作者：
Robinson, Gertraud W. [1 ]
机构：
[1] NIH, NIDDKD, Lab Genet & Physiol, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS GENETICS | 2007年 / 8卷 / 12期
关键词：
D O I：
10.1038/nrg2227
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
引用
收藏
页码：963 / 972
页数：10
相关论文
共 54 条
  • [11] Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Davenport, TG
    Jerome-Majewska, LA
    Papaioannou, VE
    [J]. DEVELOPMENT, 2003, 130 (10): : 2263 - 2273
  • [12] DEOME KB, 1959, CANCER RES, V19, P515
  • [13] REGRESSION OF MOUSE MAMMARY-GLAND ANLAGEN IN RECOMBINANTS OF TFM AND WILD-TYPE TISSUES - TESTOSTERONE ACTS VIA MESENCHYME
    DREWS, U
    DREWS, U
    [J]. CELL, 1977, 10 (03) : 401 - 404
  • [14] Dunbar ME, 1999, DEVELOPMENT, V126, P3485
  • [15] Parathyroid hormone-related protein: A developmental regulatory molecule necessary for mammary gland development
    Dunbar, ME
    Wysolmerski, JJ
    [J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1999, 4 (01) : 21 - 34
  • [16] Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Eblaghie, MC
    Song, SJ
    Kim, JY
    Akita, K
    Tickle, C
    Jung, HS
    [J]. JOURNAL OF ANATOMY, 2004, 205 (01) : 1 - 13
  • [17] Foley J, 2001, DEVELOPMENT, V128, P513
  • [18] Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling
    Gritli-Linde, Amel
    Hallberg, Kristina
    Harfe, Brian D.
    Reyahi, Azadeh
    Kannius-Janson, Marie
    Nilsson, Jeanette
    Cobourne, Martyn T.
    Sharpe, Paul T.
    McMahon, Andrew P.
    Linde, Anders
    [J]. DEVELOPMENTAL CELL, 2007, 12 (01) : 99 - 112
  • [19] Gli3-mediated repression of Hedgehog targets is required for normal mammary development
    Hatsell, Sarah J.
    Cowin, Pamela
    [J]. DEVELOPMENT, 2006, 133 (18): : 3661 - 3670
  • [20] Crosstalk between the p 1 90-B RhoGAP and lGF signaling pathways is required for embryonic mammary bud development
    Heckman, Brandy M.
    Chakravarty, Geetika
    Vargo-Gogola, Tracy
    Gonzales-Rimbau, Maria
    Hadsell, Darryl L.
    Lee, Adrian V.
    Settleman, Jeffrey
    Rosen, Jeffrey M.
    [J]. DEVELOPMENTAL BIOLOGY, 2007, 309 (01) : 137 - 149
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