Silica Core-based Surface-enhanced Raman Scattering (SERS) Tag: Advances in Multifunctional SERS Nanoprobes for Bioimaging and Targeting of Biomarkers

被引:34
作者
Jun, Bong-Hyun [1 ]
Kim, Gunsung [2 ]
Jeong, Sinyoung [2 ]
Noh, Mi Suk [3 ,4 ,5 ]
Pham, Xuan-Hung [1 ]
Kang, Homan [6 ]
Cho, Myung-Haing [3 ,4 ,7 ,8 ]
Kim, Jong-Ho [9 ]
Lee, Yoon-Sik [6 ,10 ]
Jeong, Dae Hong [2 ,6 ]
机构
[1] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 143701, South Korea
[2] Seoul Natl Univ, Dept Chem Educ, Seoul 151742, South Korea
[3] Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea
[4] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Seoul 151742, South Korea
[5] Korea Testing Certificat, Med Supplies Evaluat Ctr, Gunpo 435862, South Korea
[6] Seoul Natl Univ, Interdisciplinary Program Nano Sci & Technol, Seoul 151742, South Korea
[7] Hanyang Univ, Dept Chem Engn, Ansan 426791, South Korea
[8] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 151742, South Korea
[9] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon 443270, South Korea
[10] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151742, South Korea
来源
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2015年 / 36卷 / 03期
基金
新加坡国家研究基金会;
关键词
Silver nanoparticles; Surface-enhanced Raman scattering; Tagging materials; Cellular imaging; Au/Ag hollow-shell; BRONCHIOALVEOLAR STEM-CELLS; GOLD NANOPARTICLES; SILVER NANOPARTICLES; ACTIVE NANOSTRUCTURES; SPECTROSCOPIC TAGS; LABELS; LUNG; IMMUNOASSAY; IDENTIFICATION; FLUORESCENCE;
D O I
10.1002/bkcs.10179
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Surface-enhanced Raman scattering (SERS) has attracted considerable interest as a sensitive vibration-specific probe for bioanalytical and imaging applications. Among the various bioprobes available, Ag-embedded SERS tags have been rigorously developed for an extensive range of biodetection applications. In this review, we look at the additional functionality that SERS tags can offer via its magnetic properties, fluorescence, and an extension of the optical region into the near-infrared (NIR) spectrum. Such functionality can be achieved by using Ag nanoparticles (NPs) or Au/Ag hollow-shells (HS) as a SERS signaling unit, with SiO2 nanospheres providing a back-bone unit. This back-bone can include a magnetic core (M-SERS dots), but also provides an outer shell that protects the optical unit and allows for easy conjugation of linkers that can include fluorescent organic dyes for an additional optical unit (F-SERS dots). In use, M-SERS dots allow for the separation of target cancer or cancer stem cells with an external magnetic field, while F-SERS dots can rapidly locate specific proteins within large areas of tissue and simultaneously analyze multiple targets based on their Raman signals. Moreover, NIR SERS dots can be detected with a high sensitivity within deep tissues, thus allowing them to be applied to in vivo multiplex detection. As none of these advanced functional SERS dots exhibit any sign of cytotoxicity for cell lines, they demonstrate a clear potential for more efficient, high-throughput screening of biological molecules using Raman technology.
引用
收藏
页码:963 / 978
页数:16
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