Novel chiral ferrocenyl-imino phosphine ligands and their use in palladium catalyzed allylic alkylations

被引：21
作者：
Barbaro, P
Bianchini, C
Giambastiani, G
Togni, A
机构：
[1] Ist Chim Composti Organo Met, ICCOM CNR, Florence Res Area, I-50019 Sesto Fiorentino Firenza, Italy
[2] ETH Honggerberg, Swiss Fed Inst Technol, Dept Chem, CH-8093 Zurich, Switzerland
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 45期
关键词：
chiral ligands; ferrocenes; imino-phosphines; asymmetric catalysis;
D O I：
10.1016/j.tetlet.2003.09.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New chiral P,N-ferrocenyl imino-phosphine ligands have been synthesized and the absolute configuration of the stereocenters in each molecule has been determined by a single-crystal X-ray analysis of a common intermediate. Pd-II-allyl complexes of the new ligands have been isolated and tested as catalyst precursors in the asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate in different solvents. Quantitative yields and enantiomeric excesses as high as 80% have been obtained. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8279 / 8283
页数：5
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