Microwave assisted solvent-free synthesis of dihydropyrimidinones by Biginelli reaction over Si-MCM-41 supported FeCl3 catalyst

被引：113

作者：

Choudhary, VR ^{[1
]}

Tillu, VH ^{[1
]}

Narkhede, VS ^{[1
]}

Borate, HB ^{[1
]}

Wakharkar, RD ^{[1
]}

机构：

[1] Natl Chem Lab, Pune 411008, Maharashtra, India

来源：

CATALYSIS COMMUNICATIONS | 2003年 / 4卷 / 09期

关键词：

Biginelli reaction; synthesis of dihydropyrimidinones; FeCl3/Si-MCM-41;

D O I：

10.1016/S1566-7367(03)00111-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Among the Si-MCM-41 or montmorillonite K 10 clay supported ZnCl2, AlCl3, GaCl3, InCl3 and FeCl3 catalysts, FeCl3/Si-MCM-41 shows best performance for the microwave-assisted synthesis of dihydropyrimidinones by the Biginelli reaction involving multicomponent condensation of aromatic aldehyde, ethyl acetoacetate and urea in the absence of any solvent. It is a promising catalyst for the microwave-assisted reaction providing high product yield in a short period (3.0-5.0 min). (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：449 / 453

页数：5

共 23 条

[1] SUBSTITUTED 1,4-DIHYDROPYRIMIDINES .3. SYNTHESIS OF SELECTIVELY FUNCTIONALIZED 2-HETERO-1,4-DIHYDROPYRIMIDINES
ATWAL, KS
ROVNYAK, GC
OREILLY, BC
SCHWARTZ, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (25) : 5898 - 5907
[2] Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360
[3] Indium(III) bromide-catalyzed preparation of dihydropyrimidinones: improved protocol conditions for the Biginelli reaction
Fu, NY
Yuan, YF
Cao, Z
Wang, SW
Wang, JT
Peppe, C
[J]. TETRAHEDRON, 2002, 58 (24) : 4801 - 4807
[4] Unprecedented catalytic three component one-pot condensation reaction: An efficient synthesis of 5-alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones
Hu, EH
Sidler, DR
Dolling, UH
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (10) : 3454 - 3457
[5] Kappe CO, 1997, TETRAHEDRON, V53, P2803
[6] KAPPE CO, 1993, TETRAHEDRON, V49, P6937
[7] Synthesis and reactions of Biginelli compounds, part 19 - X-ray structure, conformational analysis, enantioseparation, and determination of absolute configuration of the mitotic kinesin Eg5 inhibitor monastrol
Kappe, CO
Shishkin, OV
Uray, G
Verdino, P
[J]. TETRAHEDRON, 2000, 56 (13) : 1859 - 1862
[8] Biologically active dihydropyrimidones of the Biginelli-type - a literature survey
Kappe, CO
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) : 1043 - 1052
[9] Polyphosphate ester-mediated synthesis of dihydropyrimidines. Improved conditions for the Biginelli reaction
Kappe, CO
Falsone, SF
[J]. SYNLETT, 1998, (07) : 718 - 720
[10] An efficient synthesis of 5-alkoxycarbonyl-4-aryl-3,4-dihydro-pyrimidin-2(1H)-ones catalyzed by KSF montmorillonite
Lin, HX
Ding, JC
Chen, XT
Zhang, ZY
[J]. MOLECULES, 2000, 5 (12): : 1240 - 1243

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