NiSO4-catalyzed C-H activation/C-S cross-coupling of 1,2,3-triazole N-oxides with thiols

被引：16
作者：
Zhu, Jiayi [1 ]
Chen, Yu [1 ]
Lin, Feng [1 ]
Wang, Baoshuang [1 ]
Chen, Zhengwang [1 ]
Liu, Liangxian [1 ]
机构：
[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 12期
关键词：
IN-VIVO EVALUATION; BOND FORMATION; ARYL; FUNCTIONALIZATIONS; THIOLATION; AMINATION; SULFIDES; AZOLES;
D O I：
10.1039/c4ob02586e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient nickel-catalyzed protocol for C-S cross-coupling through the direct functionalization of 2-aryl-1,2,3-triazole N-oxide C-H bonds with aryl or alkyl thiols, or diphenyl disulfide has been developed. The targeted N+-O- bond cleavage can be observed during the reaction, and thus obviates the need to use an additional deoxygenation step. This new protocol for the preparation of thiolated 2-aryl-1,2,3-triazoles appears to offer good yields with high regioselectivity, mild conditions, and a wide substrate scope.
引用
收藏
页码：3711 / 3720
页数：10
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